Abstract Background Huntington Disease (HD) is a neurodegenerative disorder in which caspase activation and cleavage of substrates. including the huntingtin protein. has been invoked as a pathological mechanism. Specific changes in caspase-2 (casp2) activity have been suggested to contribute to the pathogenesis of HD. https://vacuumdoctores.shop/product-category/upright-vacuum-cleaner/