Background: Low back pain is an important disorder linked with degenerative changes in the intervertebral disc (IVD). Degradation of IVD is caused by decreased number of cells. reduced production and degradation of extracellular matrix of IVD tissue especially in nucleus pulposus (NP). Natural and synthetic scaffolds are used for regeneration of IVD in tissue engineering. https://thebrickes.shop/product-category/insert-vent/